Scientific Advisory Board
Alexander Klibanov, PhD
Alexander Klibanov, PhD, Co-founder of Targeson holds a master’s degree in chemistry from Moscow State University, a PhD in biochemistry from the USSR Cardiology Research Center and the University of Tennessee. Between 1993 and 2001 he worked at Mallinckrodt, Inc., as a senior research chemist in charge of the research and manufacture of ultrasound contrast agents. He is currently an associate professor in the Division of Cardiovascular Medicine, and the Cardiovascular Research Center. He is author or coauthor of more than 60 papers related to the use of ultrasound contrast agents as targeted vehicles for imaging and therapeutic indications.
Rychak JJ, Li B, Acton ST, Leppänen A, Cummings RD, Ley K, Klibanov AL. Selectin ligands promote ultrasound contrast agent adhesion under shear flow. Mol Pharm. 2006 Sep-Oct;3(5):516-24.
Rychak JJ, Lindner JR, Ley K, Klibanov AL. Deformable gas-filled microbubbles targeted to P-selectin. J Control Release. 2006 Sep 12;114(3):288-99.
Klaus Ley, M.D.
Dr. Ley holds a MD and completed postdoctoral training in physiology and biomedical engineering in Berlin and at the University of California – San Diego. He has worked in the field of white blood cell adhesion for nearly 20 years. The physiological and biomechanical principles of his studies underlie some of Targeson’s novel site-targeted adhesive technology. Dr. Ley has received more than $12 million in NIH grants since 1994, and has published more than 200 peer-reviewed scientific papers. In 1994, Dr. Ley moved to the University of Virginia, and became director of the Robert M. Berne Cardiovascular Research Center in 2001. He oversees interdisciplinary research in basic, translational, and clinical cardiovascular sciences including cardiovascular development, function, pathophysiology, pharmacology, genetics, genomics, and proteomics. Dr. Ley is extensively involved in facilitating and supporting research that can be translated into therapies and improve patient care. Dr. Ley brings an extensive industry network, developed from years of research and consulting experience.
Ferrante EA, Pickard JE, Rychak J, Klibanov A, Ley K.Dual targeting improves microbubble contrast agent adhesion to VCAM-1 and P-selectin under flow. J Control Release. 2009 Dec 3;140(2):100-7.
Takalkar AM, Klibanov AL, Rychak JJ, Lindner JR, Ley K.Binding and detachment dynamics of microbubbles targeted to P-selectin under controlled shear flow. J Control Release. 2004 May 18;96(3):473-82.
Lindner JR, Song J, Christiansen J, Klibanov AL, Xu F, Ley K.Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin. Circulation. 2001 Oct 23;104(17):2107-12.
Robert Mattrey, M.D.
Robert Mattrey, MD, is a clinical radiologist and professor of radiology at the University of California, San Diego. He holds a BS and MS in electrical engineering, as well as an MD from the State University of New York, Buffalo. Dr. Mattrey is a pioneer in the field of contrast-enhanced ultrasound, and is active at both clinical and research levels. His research has focused on the use of ultrasound contrast agents for detecting vascular perfusion and imaging blood flow, as well as molecular imaging.
Andre MP, Steinbach G, Mattrey RF. Enhancement of the echogenicity of flowing blood by the contrast agent perflubron. Invest Radiol. 1993 Jun;28(6):502-6.
Girard MS, Kono Y, Sirlin CB, Baker KG, Deiranieh LH,Mattrey RF. B-mode enhancement of the liver with microbubble contrast agent: a blinded study in rabbits with VX2 tumors. Acad Radiol. 2001 Aug;8(8):734-40.
Lucidarme O, Kono Y, Corbeil J, Choi SH, Golmard JL, Varner J, Mattrey RF. Angiogenesis: noninvasive quantitative assessment with contrast-enhanced functional US in murine model. Radiology. 2006 Jun;239(3):730-9.
John Hossack, Ph.D.
John Hossack, PhD, holds a PhD in electrical and electronic engineering from the University of Strathclyde in Glasgow, U.K., and completed postdoctoral training at the E. L. Ginzton Laboratory of Stanford University. He later worked at Acuson, a leading diagnostic ultrasound system manufacturer (later acquired by Siemens) and joined the Department of Biomedical Engineering at UVA in 2000. Dr. Hossack is an expert in ultrasound transducer design and modeling, and has made significant contributions in the areas of 3-D imaging, beamforming, and contrast imaging.
Zhou S. Hossack JA. Dynamic-transmit focusing using time-dependent focal zone and center frequency. IEEE Trans. Ultrason. Ferroelectr. Freq. Control. 2003; 50(2):142-52.
Rychak JJ, Klibanov AL, Hossack JA. Acoustic radiation force enhances targeted delivery of ultrasound contrast microbubbles: in vitro verification. IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Mar; 52(3):421-33.
Hossack JA, Sumanaweera TS, Napel S, Ha JS. Quantitative 3D diagnostic ultrasound imaging using a modified transducer array and an automated image tracking technique. IEEE Trans Ultrason Ferroelectr Freq Control. 2002; 49(8):1029-38.
Paul Dayton, Ph.D.
Paul Dayton, PhD, is a 1995 graduate in physics and comprehensive science of Villanova University. He received his ME degree in electrical engineering and his PhD degree in biomedical engineering from UVa, in 1998 and 2001, respectively. Dr. Dayton conducted postdoctoral research at the University of California, Davis, and subsequently accepted a position as associate research professor there. At UC Davis, Dr. Dayton’s research involved advancing the field of molecular imaging with ultrasound through the design of new contrast agents and imaging methods. Dr. Dayton joined the UNC-NCSU Joint Department of Biomedical Engineering in the fall of 2007.
Talu E, Hettiarachchi K, Zhao S, Powell RL, Lee AP, Longo ML, Dayton PA. Tailoring the size distribution of ultrasound contrast agents: possible method for improving sensitivity in molecular imaging. Mol Imaging. 2007 Nov-Dec;6(6):384-92.
Zhao S, Kruse DE, Ferrara KW, Dayton PA.Selective imaging of adherent targeted ultrasound contrast agents. Phys Med Biol. 2007 Apr 21;52(8):2055-72.
Zhao S, Kruse DE, Ferrara KW, Dayton PA. Acoustic response from adherent targeted contrast agents. J Acoust Soc Am. 2006 Dec;120(6):EL63-9.
Detlef Schuppan, M.D., Ph.D.
Detlef Schuppan, M.D., Ph.D. is Associate Professor of Medicine, Harvard Medical School, Boston, MA, Division of Gastroenterology, Beth Israel Deaconess Medical Center. In addition to being a fully licensed medical doctor seeing gastroenterology patients, Dr. Schuppan is a world-renowned researcher. In 1997, he discovered tissue transglutaminase as the autoantigen for celiac disease, a common inflammatory ailment triggered by wheat proteins. He has published over 280 original papers in high-impact scientific journals, including Science and nature Medicine. Dr. Schuppan currently works on liver fibrosis, liver and gastrointestinal cancers. He has also several papers and patents on novel molecular imaging methods, including work with contrast-enhanced ultrasound.