Scientific Advisory Board
Klaus Ley, Chairman
Dr. Ley holds a MD and completed postdoctoral training in physiology and biomedical engineering in Berlin and at the University of California - San Diego. He has worked in the field of white blood cell adhesion for nearly 20 years. The physiological and biomechanical principles of his studies underlie some of Targeson’s novel site-targeted adhesive technology. Dr. Ley has received more than $12 million in NIH grants since 1994, and has published more than 200 peer-reviewed scientific papers. In 1994, Dr. Ley moved to the University of Virginia, and became director of the Robert M. Berne Cardiovascular Research Center in 2001. He oversees interdisciplinary research in basic, translational, and clinical cardiovascular sciences including cardiovascular development, function, pathophysiology, pharmacology, genetics, genomics, and proteomics. Dr. Ley is extensively involved in facilitating and supporting research that can be translated into therapies and improve patient care. Dr. Ley brings an extensive industry network, developed from years of research and consulting experience.
Robert Mattrey, M.D.
Dr. Mattrey is a clinical radiologist and Professor of Radiology at the University of California, San Diego. He holds a BS and MS in Electrical Engineering, as well as an MD from the State University of New York, Buffalo. Dr. Mattrey is a pioneer in the field of contrast enhanced ultrasound, and is active at both clinical and research levels. Dr. Mattrey’s research has focused upon the use of ultrasound contrst agents for detecting vascular perfusion and imaging blood flow, as well as molecular imaging.
Andre MP, Steinbach G, Mattrey RF. Enhancement of the echogenicity of flowing blood by the contrast agent perflubron. Invest Radiol. 1993 Jun;28(6):502-6.
Girard MS, Kono Y, Sirlin CB, Baker KG, Deiranieh LH,Mattrey RF. B-mode enhancement of the liver with microbubble contrast agent: a blinded study in rabbits with VX2 tumors. Acad Radiol. 2001 Aug;8(8):734-40.
Lucidarme O, Kono Y, Corbeil J, Choi SH, Golmard JL, Varner J, Mattrey RF. Angiogenesis: noninvasive quantitative assessment with contrast-enhanced functional US in murine model. Radiology. 2006 Jun;239(3):730-9.
John Hossack, Ph.D.
Dr. Hossack holds a PhD in Electrical and Electronic Engineering from the University of Strathclyde in Glasgow, UK, and completed postdoctoral training at the E. L. Ginzton Laboratory of Stanford University. He later worked at Acuson - a leading diagnostic ultrasound system manufacturer (later acquired by Siemens) - and joined the Department of Biomedical Engineering at the University of Virginia in 2000. Dr. Hossack is an expert in ultrasound transducer design and modeling, and has made significant contributions in the areas of 3D imaging, beamforming and contrast imaging.
Zhou S. Hossack JA. Dynamic-transmit focusing using time-dependent focal zone and center frequency. IEEE Trans. Ultrason. Ferroelectr. Freq. Control. 2003; 50(2):142-52.
Rychak JJ, Klibanov AL, Hossack JA. Acoustic radiation force enhances targeted delivery of ultrasound contrast microbubbles: in vitro verification. IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Mar; 52(3):421-33.
Hossack JA, Sumanaweera TS, Napel S, Ha JS. Quantitative 3D diagnostic ultrasound imaging using a modified transducer array and an automated image tracking technique. IEEE Trans Ultrason Ferroelectr Freq Control. 2002; 49(8):1029-38.
Paul Dayton, Ph.D.
Dr. Dayton is a 1995 graduate in physics and comprehensive science of Villanova University. He received his M.E. degree in electrical engineering and his Ph.D. degree in biomedical engineering from the University of Virginia, Charlottesville, VA, in 1998 and 2001, respectively. His graduate research in the lab of Katherine Ferrara centered on studies of ultrasound contrast agents, and as a doctoral student, Dr. Dayton developed two of the worlds’ first ultra-high speed optical microscopy imaging systems for physical analysis of contrast agents. Dr. Dayton conducted postdoctoral research at the University of California, Davis, and subsequently accepted a position as associate research professor at the same institution. Dr. Dayton joined the UNC-NCSU Joint Department of Biomedical Engineering in the fall of 2007. At UC Davis, Dr. Dayton’s research involves advancing the field of molecular imaging with ultrasound through the design of new contrast agents and imaging methods. His current research interests continue to be in the area of contrast agents and molecular imaging with ultrasound, and other interests include general medical imaging, ultrasound enhanced therapeutics, high-speed optical imaging, medical devices, and engineering design.
Talu E, Hettiarachchi K, Zhao S, Powell RL, Lee AP, Longo ML, Dayton PA. Tailoring the size distribution of ultrasound contrast agents: possible method for improving sensitivity in molecular imaging. Mol Imaging. 2007 Nov-Dec;6(6):384-92.
Zhao S, Kruse DE, Ferrara KW, Dayton PA.Selective imaging of adherent targeted ultrasound contrast agents. Phys Med Biol. 2007 Apr 21;52(8):2055-72.
Zhao S, Kruse DE, Ferrara KW, Dayton PA. Acoustic response from adherent targeted contrast agents. J Acoust Soc Am. 2006 Dec;120(6):EL63-9.
Alexander Klibanov, PhD
Dr. Klibanov holds a Masters Degree in Chemistry from Moscow State University, and a PhD in Biochemistry from the Cardiology Research Center in Russia. Dr. Klibanov has extensive experience designing and manufacturing ultrasound contrast agents, and was one of the origional co-inventors of much of the current generation of ultrasound contrast agents. He is author or co-author of more than 60 papers related to the use ultrasound contrast agents as targeted vehicles for imaging and therapeutic indications. Between 1993 and 2001, he worked at Mallinckrodt, Inc as a Senior Research Chemist in charge of the research and manufacture of ultrasound contrast agents. He is currently an Associate Professor in the Division of Cardiovascular Medicine, and the Cardiovascular Research Center.
Rychak JJ, Li B, Acton ST, Leppänen A, Cummings RD, Ley K, Klibanov AL. Selectin ligands promote ultrasound contrast agent adhesion under shear flow. Mol Pharm. 2006 Sep-Oct;3(5):516-24.
Rychak JJ, Lindner JR, Ley K, Klibanov AL. Deformable gas-filled microbubbles targeted to P-selectin. J Control Release. 2006 Sep 12;114(3):288-99.