Targestar P

Targestar P is a non-targeted perfusion contrast agent designed to enhance and quantify blood flow and vascular function

  • Liver in healthy mouse, imaged at 14 MHz

  • Kidney in dog, showing cyst

  • Diabetic mouse showing kidney and liver (courtesy K. Sharma, UCSD)

  • Liver in diabetic mouse showing delayed parenchymal perfusion (courtesy K. Sharma, UCSD)

  • Liver in diabetic mouse, dual mode, showing regions of hypoperfusion

  • Healthy mouse showing kidney and adjacent organs

  • Liver in healthy mouse, imaged at 8 MHz

  • Liver in healthy mouse, imaged at 14 MHz

  • Contraction of left ventricle in healthy mouse (14 MHz)

  • Arterial and microcirculatory flow in mouse hindlimb

  • Intact kidney in mouse shows cortico-medullary flow gradient.

  • Kidney in mouse with renal artery ligated shows no perfusion

  • Perfusion imaging of a complex tumor shows two regions of necrosis (arrows)

  • Perfusion imaging of a complex tumor shows two regions of necrosis (arrows)

  • Perfusion of syngeneic bladder cancer tumor (MB-49) on mouse flank

  • Perfusion of syngeneic bladder cancer tumor (MB-49) on mouse flank

  • Persistance imaging in Subcutaneous mouse tumor, 40 MHz

  • B-mode and contrast imaging of PC-3 tumor showing central necrosis

  • Subcutaneous human prostate carcinoma (PC-3) showing central necrosis

  • Mid-abdominal scan in mouse model of inflammatory bowel disease

  • Abdominal scan showing colon and cecum

Applications

The Targestar family of products can be used to image perfusion using real-time ultrasound.  Targestar P is restricted to the vascular compartment and enables visualization of the vasculature and quantification of blood flow.  Agent echogenicity is optimal at ultrasound frequencies in 1-15 MHz range. Contrast imaging settings such as pulse inversion or CPS must be enabled on the ultrasound scanner for optimal contrast sensitivity. The agent remains acoustically active for 5-15 minutes, depending on the administered dose. Optimal dosages vary with application.

Directions for Use

Targestar P is an ultrasound contrast agent to be used for vascular imaging and quantitation of blood flow in small animal models of disease. Agents may be administered as an intravenous bolus injection for routine contrast ultrasound imaging, or as a continuous venous infusion for sensitive perfusion measurements. Bolus administration can be accomplished via retro-orbital, tail vein, or jugular injection in mice.

Specifications

Targestar P is a microbubble contrast agent for imaging blood flow and vascular perfusion. The contrast agent is a  intravascular tracer. Each vial contains approximately 10 mouse doses.