Ultrasound molecular imaging with targeted microbubble contrast agents.
Klibanov AL. Ultrasound molecular imaging with targeted microbubble contrast agents. J Nucl Cardiol. 2007 Nov-Dec;14(6):876-84.
Targeson’s founders, collaborators, and customers have published extensively in the field of ultrasound-based molecular and functional imaging. Below is a list of selected recent publications using Targeson and related microbubble technology.
Microultrasound molecular imaging of vascular endothelial growth factor receptor 2 in a mouse model of tumor angiogenesis.
Rychak JJ, Graba J, Cheung AM, Mystry BS, Lindner JR, Kerbel RS, Foster FS. Microultrasound molecular imaging of vascular endothelial growth factor receptor 2 in a mouse model of tumor angiogenesis. Mol Imaging. 2007 Sep-Oct;6(5):289-96.
Molecular ultrasound imaging using microbubble contrast agents
Dayton PA, Rychak JJ.Molecular ultrasound imaging using microbubble contrast agents. Front Biosci. 2007 Sep 1;12:5124-42.
Microbubble-enhanced ultrasound to deliver an antisense oligodeoxynucleotide targeting the human androgen receptor into prostate tumours
Haag P, Frauscher F, Gradl J, Seitz A, Schäfer G, Lindner JR, Klibanov AL, Bartsch G, Klocker H, Eder IE. Microbubble-enhanced ultrasound to deliver an antisense oligodeoxynucleotide targeting the human androgen receptor into prostate tumours. J Steroid Biochem Mol Biol. 2006 Dec;102(1-5):103-13.
Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow.
Klibanov AL, Rychak JJ, Yang WC, Alikhani S, Li B, Acton S, Lindner JR, Ley K, Kaul S. Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow. Contrast Media Mol Imaging. 2006 Nov;1(6):259-66.
Deformable gas-filled microbubbles targeted to P-selectin.
Rychak JJ, Lindner JR, Ley K, Klibanov AL. Deformable gas-filled microbubbles targeted to P-selectin. J Control Release. 2006 Sep 12; 114: 288-299.
Selectin ligands promote ultrasound contrast agent adhesion under shear flow.
Rychak JJ, Li B, Acton ST, Leppanen A, Cummings RD, Ley K, Klibanov AL. Selectin ligands promote ultrasound contrast agent adhesion under shear flow. Mol Pharm. 2006 Sep-Oct; 3: 516-524.
Targeting mucosal addressin cellular adhesion molecule (MAdCAM)-1 to noninvasively image experimental Crohn’s disease.
Bachmann C, Klibanov AL, Olson TS, Sonnenschein JR, Rivera-Nieves J, Cominelli F, Ley KF, Lindner JR, Pizarro TT. Targeting mucosal addressin cellular adhesion molecule (MAdCAM)-1 to noninvasively image experimental Crohn’s disease. Gastroenterology. 2006 Jan;130(1):8-16.
Assessment of endogenous and therapeutic arteriogenesis by contrast ultrasound molecular imaging of integrin expression
Leong-Poi H, Christiansen J,Heppner P, Lewis CW, Klibanov AL, Kaus S, Lindner JR. Assessment of endogenous and therapeutic arteriogenesis by contrast ultrasound molecular imaging of integrin expression. Circulation. 2005 Jun 21; 111(224):3248-54.
Microbubbles in medical imaging: current applications and future directions
Lindner JR. Microbubbles in medical imaging: current applications and future directions. Nat Rev Drug Discov. 2004 Jun;3(6):527-32.
Binding and detachment dynamics of microbubbles targeted to P-selectin under controlled shear flow
Takalkar AM, Klibanov AL, Rychak JJ, Lindner JR, Ley K. Binding and detachment dynamics of microbubbles targeted to P-selectin under controlled shear flow. J Control Release. 2004 May 18;96(3):473-82.
Targeted tissue transfection with ultrasound destruction of plasmid-bearing cationic microbubbles
Christiansen JP, French BA, Klibanov AL, Kaul S, Lindner JR. Targeted tissue transfection with ultrasound destruction of plasmid-bearing cationic microbubbles. Ultrasound Med Biol. 2003 Dec;29(12):1759-67.
Noninvasive assessment of angiogenesis by ultrasound and microbubbles targeted to alpha(v)-integrins
Leong-Poi H, Christiansen J, Klibanov AL, Kaul S, Lindner JR. Noninvasive assessment of angiogenesis by ultrasound and microbubbles targeted to alpha(v)-integrins. Circulation. 2003 Jan 28;107(3):455-60.
Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin
Lindner JR, Song J, Christiansen J, Klibanov AL, Xu F, Ley K. Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin. Circulation. 2001 Oct 23;104(17):2107-12.
Microbubble contrast agents: targeted ultrasound imaging and ultrasound-assisted drug-delivery applications.
Klibanov AL. Microbubble contrast agents: targeted ultrasound imaging and ultrasound-assisted drug-delivery applications. Invest. Radiol. 2006 Mar; 41: 354-362.