Publications
Targeson’s founders, collaborators, and customers have published extensively in the field of ultrasound-based molecular and functional imaging. Below is a list of selected recent publications using Targeson and related microbubble technology.
A Triple-Targeted Ultrasound Contrast Agent Provides Improved Localization to Tumor Vasculature
Warram JM, Sorace AG, Saini R, Umphrey HR, Zinn KR, Hoyt K. A Triple-Targeted Ultrasound Contrast Agent Provides Improved Localization to Tumor Vasculature. J Ultrasound Med. 2011 July; 30(7): 921–931
Model System Using Controlled Receptor Expression for Evaluating Targeted UItrasound Contrast Agents
Saini R, Warram JM, Sorace AG, Umphrey H, Zinn KR, Hoyt K. Model System Using Controlled Receptor Expression for Evaluating Targeted Ultrasound Contrast Agents. Ultrasound Med Biol. 2011 Aug;37(8):1306-13.
Real-Time Technique for Improving Molecular Imaging and Guiding Drug Delivery in Large Blood Vessels: In Vitro and Ex Vivo Results
Patil AV, Rychak JJ, Klibanov AL, Hossack JA. Real-Time Technique for Improving Molecular Imaging and Guiding Drug Delivery in Large Blood Vessels: In Vitro and Ex Vivo Results. Mol Imaging. 2011 Apr 26.
Ultrasound molecular imaging of tumor angiogenesis with an integrin targeted microbubble contrast agent
Anderson CR, Hu X, Zhang H, Tlaxca J, Decleves AE, Houghtaling R, Sharma K, Lawrence M, Ferrara KW, Rychak JJ. Ultrasound molecular imaging of tumor angiogenesis with an integrin targeted microbubble contrast agent. Invest Radiol. 2011 Apr;46(4):215-24.
scVEGF microbubble ultrasound contrast agents: a novel probe for ultrasound molecular imaging of tumor angiogenesis
Anderson CR, Rychak JJ, Backer M, Backer J, Ley K, Klibanov AL. scVEGF microbubble ultrasound contrast agents: a novel probe for ultrasound molecular imaging of tumor angiogenesis. Invest Radiol. 2010 Oct;45(10):579-85.
Analysis of in vitro Transfection by Sonoporation Using Cationic and Neutral Microbubbles
Tlaxca JL, Anderson CR, Klibanov AL, Lowrey B, Hossack JA, Alexander JS, Lawrence MB, Rychak JJ. Analysis of in vitro Transfection by Sonoporation Using Cationic and Neutral Microbubbles. Ultrasound Med Biol. 2010 Aug 27.
Advances in molecular imaging with ultrasound
Gessner R, Dayton PA. Advances in molecular imaging with ultrasound. Mol Imaging 2010 Jun;9(3):117-27. Review.
Molecular imaging of myocardial and vascular disorders with ultrasound
Lindner JR. Molecular imaging of myocardial and vascular disorders with ultrasound. JACC Cardiovasc Imaging. 2010 Feb;3(2):204-11. Review.
Dual targeting improves microbubble contrast agent adhesion to VCAM-1 and P-selectin under flow
Ferrante EA, Pickard JE, Rychak J, Klibanov A, Ley K. Dual targeting improves microbubble contrast agent adhesion to VCAM-1 and P-selectin under flow. J Control Release. 2009 Dec 3;140(2):100-7.
Detection of VCAM-1 Expression in Inflammatory Atherosclerosis Using Targeted Ultrasound-based Molecular Imaging
Driessen WH, Danila DC, Conyers JL, McPherson DD, Kee P. Expression in Inflammatory Atherosclerosis Using Targeted Ultrasound-based Molecular Imaging. Circulation. 2009;120:S326.
Dual frequency method for simultaneous translation and real-time imaging of ultrasound contrast agents within large blood vessels
Patil AV, Rychak JJ, Allen JS, Klibanov AL, Hossack JA. Dual frequency method for simultaneous translation and real-time imaging of ultrasound contrast agents within large blood vessels. Ultrasound Med Biol. 2009 Dec;35(12):2021-30.
A method for differentiating targeted microbubbles in real time using subharmonic micro-ultrasound and interframe filtering
Needles A, Couture O, Foster FS. A method for differentiating targeted microbubbles in real time using subharmonic micro-ultrasound and interframe filtering. Ultrasound Med Biol. 2009 Sep;35(9):1564-73.
Specific Targeting of Human Inflamed Endothelium and In Situ Vascular Tissue Transfection by the Use of Ultrasound Contrast Agents
Barreiro O, Aguilar RJ, Tejera E, Megías D, de Torres-Alba F, Evangelista A, Sánchez-Madrid F. Specific Targeting of Human Inflamed Endothelium and In Situ Vascular Tissue Transfection by the Use of Ultrasound Contrast Agents. JACC Cardiovasc Imaging. 2009 Aug;2(8):997-1005.
Ultrasound molecular imaging with targeted microbubble contrast agents
Klibanov AL. Ultrasound molecular imaging with targeted microbubble contrast agents. J Nucl Cardiol. 2007 Nov-Dec;14(6):876-84.
Microultrasound molecular imaging of vascular endothelial growth factor receptor 2 in a mouse model of tumor angiogenesis
Rychak JJ, Graba J, Cheung AM, Mystry BS, Lindner JR, Kerbel RS, Foster FS. Microultrasound molecular imaging of vascular endothelial growth factor receptor 2 in a mouse model of tumor angiogenesis. Mol Imaging. 2007 Sep-Oct;6(5):289-96.
Enhanced targeting of ultrasound contrast agents using acoustic radiation force
Rychak JJ, Klibanov AL, Ley KF, Hossack JA. Enhanced targeting of ultrasound contrast agents using acoustic radiation force. Ultrasound Med Biol. 2007 Jul;33(7):113-9. Epub 2007 Apr 18.
Molecular ultrasound imaging using microbubble contrast agents
Dayton PA, Rychak JJ. Molecular ultrasound imaging using microbubble contrast agents. Front Biosci. 2007 Sep 1;12:5124-42.
Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow
Klibanov AL, Rychak JJ, Yang WC, Alikhani S, Li B, Acton S, Lindner JR, Ley K, Kaul S. Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow. Contrast Media Mol Imaging. 2006 Nov;1(6):259-66.
Deformable gas-filled microbubbles targeted to P-selectin
Rychak JJ, Lindner JR, Ley K, Klibanov AL. Deformable gas-filled microbubbles targeted to P-selectin. J Control Release. 2006 Sep 12; 114: 288-299.
Selectin ligands promote ultrasound contrast agent adhesion under shear flow
Rychak JJ, Li B, Acton ST, Leppanen A, Cummings RD, Ley K, Klibanov AL. Selectin ligands promote ultrasound contrast agent adhesion under shear flow. Mol Pharm. 2006 Sep-Oct; 3: 516-524.
Targeting mucosal addressin cellular adhesion molecule (MAdCAM)-1 to noninvasively image experimental Crohn’s disease
Bachmann C, Klibanov AL, Olson TS, Sonnenschein JR, Rivera-Nieves J, Cominelli F, Ley KF, Lindner JR, Pizarro TT. Targeting mucosal addressin cellular adhesion molecule (MAdCAM)-1 to noninvasively image experimental Crohn’s disease. Gastroenterology. 2006 Jan;130(1):8-16.
Acoustic radiation force enhances targeted delivery of ultrasound contrast microbubbles: in vitro verification
Rychak JJ, Klibanov AL, Hossack JA. Acoustic radiation force enhances targeted delivery of ultrasound contrast microbubbles: in vitro verification. IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Mar;52(3):421-33.
Binding and detachment dynamics of microbubbles targeted to P-selectin under controlled shear flow
Takalkar AM, Klibanov AL, Rychak JJ, Lindner JR, Ley K. Binding and detachment dynamics of microbubbles targeted to P-selectin under controlled shear flow. J Control Release. 2004 May 18;96(3):473-82.
Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin
Lindner JR, Song J, Christiansen J, Klibanov AL, Xu F, Ley K. Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin. Circulation. 2001 Oct 23;104(17):2107-12.